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This matrix, secured in the lesion website via fibrin glue, has constantly been affiliated with the AMIC method since 1999 to stabilize the Tremendous clot on top of the lesion immediately after MF, avoiding the lack of MSCs in the joint space and, simultaneously, assuring the chondrogenic differentiation of these cells [70,71]. Other organic matrices employed by some authors for AMIC were HA-dependent or hyaluronan kinds [31,32].

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Table four. optimistic correlations among people/lesions capabilities and clinical effects. NO = studies that analyzed the correlations, but didn't find a correlation; / = experiments that didn't take the correlation into account.

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various restrictions were being recognized inside the included experiments. These involve the general very low methodological high quality, specifically a result of the absence of electricity analyses, blinding, and randomization. In addition, The shortage of RCTs as well as the confined number of comparative scientific tests drastically weaken the toughness with the accessible evidence.

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